February 9, 2010

Cranberry found to be effective for urinary tract infection prevention in girls

Urinary tract infections are common in women, and for some women can be recurrent and require repeated doses of antibiotics or even prophylactic antibiotics. Organisms (usually E. coli) that cause UTIs generally gain access to the bladder via the urethra (the pipe connecting the bladder with the outside). Some of the strategies that may help to prevent UTI is to drink plenty of water (to help flush the bladder and urethra of organism), urinating quite soon are sexual intercourse (intercourse increases the risk of organisms being introduced into the urethra) and wiping after going to the toilet from front to back (reducing the risk that organisms will be introduced into the urethra).

In addition, certain natural agents can help, and perhaps the most well known of these is cranberry. Research has discovered that cranberry has the ability to reduce the ability of E. coli organisms to ‘stick’ to the lining of the urinary tract. This means that E. coli has less capacity to set up camp in the urinary tract, and is therefore more likely to be flushed out of the body before it causes a bona fide infection.

Previous studies have found that cranberry supplementation has the capacity to reduce the risk of UTIs. See here and here for previous posts which have reported on relevant research in this area.

More recently, further research has found that cranberry may be an effective UTI preventer in the young [1]. In a study published in the Scandinavian Journal of Urology and Nephrology, girls aged 3-14 were treated with cranberry juice, or a probiotic, or nothing for a period of 6 months. The dose of cranberry was just 50 mls of juice, taken daily.

At the end of the study, rates of urinary tract infection in the cranberry, probiotic and control groups were about 18, 42 and 48 per cent respectively. The lower rate of UTI in the cranberry group was statistically significant.

Reading about this study reminded of another natural remember for UTIs which come in the form of D-mannose (a sugar). Like cranberry, D-mannose affects adhesion of E. coli to the urinary tract. It can be used in the treatment and prevention of UTIs in both children and adults.

For more details about D-mannose and how to use it, see here.

References:

1. Ferrara P, et al. Cranberry juice for the prevention of recurrent urinary tract infections: a randomized controlled trial in children. Scand J Urol Nephrol 2009;43(5):369-72.

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February 8, 2010

My friend’s son reminds me how important blood sugar control is to energy and mood

I was talking to a son of a friend of mine over the weekend. Mark (not his real name) is 18 and has been finding his energy and motivation can flag at times. Some of the time he can be energised and motivated. Other times he feels lethargic and “can’t be bothered with life”. Naturally, the focus on this issue has been on his life circumstances, but I was also interested to explore if physiological or biochemical factors may be playing some part in his symptoms.

I asked Mark if his symptoms appeared to have any relationship to food. He said others had noticed that his mood improves, at least momentarily on eating. There are many reasons why someone may feel cheerier for eating including, of course, the deriving of pleasure from food. One other important reason individuals may feel better for eating is that they have come into that meal with low levels of blood sugar (hypoglycaemia).

Because the brain generally uses a lot of sugar, under-fuelling of the brain through hypoglycaemia can cause it to malfunction. Low mental energy and low mood are potential symptoms of hypoglycaemia. When blood sugar levels are improved by eating, it can lead to an improvement in energy and outlook too.

I have found over the years that blood sugar instability is a major cause of fluctuation in mood and energy. This has not just been my professional experience, but my personal experience too. Many years ago (when my diet was much richer in carbohydrate) I was quite prone to what I take to be spells of hypoglycaemia myself.

While I talking to Mark I remembered how I would sit as medical student in teaching hospital clinics or lectures in the afternoon (a danger time for hypoglycaemia) feeling tired, unable to concentrate and often utterly demotivated. Later on I began to realise that at least a large part of these issues were down to my awry blood sugar control. This was picked up on by others too. For example, if I was grumpy those who knew me well (a girlfriend, say) would urge me to ‘eat something’. One of my friends, a doctor, suggested that I was Snow White’s eighth dwarf – going under the name of ‘hypo’.

I have learned, likes many others, that getting the diet right is key to stabilising blood sugar levels. There are two fundamental here: eating foods that release sugar relatively slowly into the bloodstream, and eating those foods regularly enough.

I asked Mark about his diet. A lot of his diet turned out to be generally disruptive for blood sugar (Subway sandwiches, burgers and fries, mounds of pasta). His eating was also quite irregular. I asked about breakfast. His reply was “I don’t see the point of breakfast”. I asked him what he meant by this and he replied “When I eat breakfast I’m starving an hour later.” When I asked him what he might have for breakfast it turned out to be cereal.

His experience here is relatively common. I quite often hear individuals tell me they are hungrier in the morning after the eat breakfast than if they don’t. This, I think, is another symptom of impaired blood sugar regulation. Typical breakfast fare such as toast and cereal tend to induce surges of blood sugar which, in turn, can cause large quantities of insulin to be secreted by the pancreas. One of the chief functions of insulin is to reduce blood sugar levels, but a glut of insulin can cause hypoglycaemia, which can cause individuals to be hungry (typically for carbohydrate-rich foods).

My advice was to scale back the carbs a bit, up the protein, and to eat more regularly (including healthy snacks if he gets peckish between meals). Cutting back on carbs and eating more regularly should help to ensure a steadier supply of fuel into the brain. More protein should help here too. But another trick that protein has up its sleeve is the fact that it is made of amino acids, and these supply the building blocks of brain chemicals (neurotransmitters) that can have a profound effect on mood and brain energy (including dopamine, noradrenaline and serotonin).

Giving advice is no guarantee that someone will act on it. However, my experience tells me that if Mark adjusts his diet in the way I outline here he will see quite immediate benefit in terms of his energy and mood. I know it did with me, and I’ve seen it work for countless others too.

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