The supposed ‘gold standard’ method of medical research is the ‘randomised controlled trial’. What this means in drug therapy research is that a group of individuals are randomly assigned to the treatment being studied or placebo, and the outcomes and effects compared. In the ‘best’ trials, neither the study participant not the investigators know who […]
Search results for "statin"
Article reveals unseen cause of bias that risks compromising the evidence-base for statins and other drugs
I have written more than once about Professor Sir Rory Collins. He leads the Cholesterol Treatment Trialists collaboration in Oxford, UK. Periodically, this group takes (private) statin study data and churns out bold pronouncements on the (supposed) great effectiveness and safety of these drugs. Professor Collins recently tried to get the BMJ to retract two […]
Professor Sir Rory Collins is one of the most strident advocates of statin therapy, and also leads a ‘research group’ known as the Cholesterol Treatment Trialists collaboration (CTT). Professor Collins and his colleagues hold a huge database of from statin studies, and quite-often ‘crunch the numbers’ and pronounce statins to be highly effective and very […]
Those keen to optimise their cardiovascular health and reduce their risk of heart attack and stroke may well, in addition to ‘eating right’, take steps to ‘take exercise’ and be physically fit. Usually, the prescribed exercise here come in the form of ‘cardiovascular’ or ‘aerobic’ forms such as walking, jogging, cycling or rowing. Such activities […]
Last month, one of my blog posts featured a letter written by a group of doctors, expressing their concerns about the mooted expansion of statin therapy. The letter detailed six major objections to the plan, including the mass-medicalization of millions of healthy individuals, the unreliability of the evidence regarding the adverse effects of statins, and […]
The debate about the safety of statins continues to rage, with some researchers claiming that they are essentially no more harmful that placebo. In reality, though, the evidence on which these claims are based is flawed for several reasons. Here are just some of those reasons: 1. Commercial sponsors of clinical trials may not be […]
There are, to my mind, two camps of doctors in terms of their attitude to statins. Some maintain these drugs are ‘highly effective’ and very safe (and might even be put in the water supply). Others (who bother to look objectively at the research) tell us that statins only help a small minority of people […]
Clowns to the left of me, jokers to the right (why won’t those calling for statin papers to be retracted use some science?)
On 21 May my blog featured calls by Professor Sir Rory Collins for the retraction of two articles that raised issues about the safety of statins. In both articles, evidence from a particular study was misrepresented and misquoted. The BMJ has withdrawn the comments and even featured them in an editorial. But Professor Sir Rory […]
Earlier this year, the National Institute for Health and Care Excellence (NICE) suggested a reduction in the threshold beyond which statin therapy should be considered (from a 10-year risk of cardiovascular disease of 20 per cent to 10 per cent). Some people believe this can only be a good thing. I believe that these people […]
This week, the BMJ has published a study that adds further to the debate regarding the safety of statins. It is officially recognised that one potential adverse-effect of statins is the development of diabetes. In this study, Canadian researchers pooled the results of several studies to see if the risk of diabetes was higher in […]
Recent Blog Posts
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- Article reveals unseen cause of bias that risks compromising the evidence-base for statins and other drugs
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- How accurate are Professor Collins’ claims about the rates of muscle problems with statins?
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Dr Briffa’s tweets
New post: How accurate are Professor Rory Collins's claims about muscle-related adverse effects of statins? drbriffa.com/2014/08/22/how…
Jerome Burne provides an amusing if slightly depressing analysis of the crown prince of statin therapy - Professor Rory Collins @JeromeJB
British Medical Journal launches fantastic initiative: An opportunity for 'ordinary people' to help set the research agenda @bmj_latest
Study shines light on the fact that sunscreens don't appear to offer real protection against melanoma drbriffa.com/2014/06/13/stu…
Prof Sever invokes 'evidence' in calling for retraction of statin papers. Shame he uses bad science to make his case bmj.com/content/348/bm…
New post: Why won't those calling for retraction of BMJ statin articles actually use some science? drbriffa.com/2014/06/11/clo…
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