Can higher-protein diets help weight loss maintenance?

A lot of people find they can lose excess weight reasonably effectively. However, maintaining that weight loss can be another matter. It’s not uncommon for the pounds that have been shed to slowly return, often with a bit of additional interest too. The reasons for failure in this respect are varied and are perhaps the subject of a separate post, but they include a slide back to less healthy eating, and the fact that caloric restriction can put a dent in the metabolism.

The chronic failure of weight loss diets in the long term have led some doctors and scientists to explore what factors might affect the loss maintenance. One such study was published recently on-line in the American Journal of Clinical Nutrition [1]. In this this piece of research, overweight and obese study subjects (average BMI 39) were subjected to a very low calorie diet (500-550 calories per day ) for three months. At the end of this intervention, average weight loss was 16.5 kg (36 lbs). After this initial phase, the group was then randomised to eat either a high-carb diet or a high-protein diet for a year. The prescribed diets contained 15 and 30 per cent protein respectively. Both groups were advised to keep fat intake to less than 30 per cent of calories. Subjects were advised of the number of calories to consume that, theoretically, should maintain their weight.

During this phase subjects generally gained weight, but still ended up an average of 14.5 kg lighter than their original starting weight. There was no significant difference between the high-protein and high-carb groups, which might lead some to conclude the higher protein diets have no particular merit over lower ones.

However, while one prescribed diet had twice the protein level of the other (30 v 15 per cent), the subjects may have ended up having more similar protein intakes than this. Protein intakes were calculated using food diaries and urine analysis (urea). Average protein intakes were calculated to be 30.2 and 21.7 per cent respectively. However, the number of people completing these tests was very low. And normally, it’s the most compliant individuals that are most motivated to fill out food diaries or have other assessment of compliance.

Other studies have found that higher-protein diets may have some advantages regarding the maintenance of weight loss or fat loss. In one study of similar design to the one above, individuals were put on a low-calorie diet for a month [2]. After this, individuals were split into two groups, one of which had their diet supplemented with 30 g of protein each day over a 6-month period. The protein-supplemented group regained less than 1 kg in weight, compared to 3 kg in the other group. However, none of the weight regained in the protein-supplemented group came in the form of fat. This was not true for the other group, however. Higher protein intake was also associated with a reduction in waist circumference, compared to a gain in the other group.

In another study [3], obese individuals were put on a very low-calorie diet for 5-6 weeks to induce weight loss. After this, though, individuals were instructed to eat a low-fat diet. Some of the individuals supplemented their diet with carbohydrate (in the form of maltodextrin), while others supplemented their diet with protein (50 g of casein or whey protein each day). Individuals could eat as much of their new diet as they liked for a period of 12 weeks, at which point they were assessed in terms of weight and various biochemical measurements.

At the end of the study, compared to the carb-supplemented individuals, those supplemented with protein lost an average of 2.3 kg more. Crucially, this lost weight was almost entirely composed of fat.

Other research had individuals eat either a higher protein (1.6 grams of protein per kg of body weight per day) or lower protein (0.8 grams of protein per kg of body weight per day) for a year [17]. The first four months was designed to provide individuals with a calorie deficit of 500 calories a day, and for the following 8 months the calorie intake was designed for weight maintenance (rather than loss). At the end of the year, while weight loss was not significantly different between the two groups, fat loss was: those on the higher protein diet did better on this measure. As a group, they had improved body composition (more lean body mass and less fat) compared to those eating the lower-protein diet.

This last finding ” improved body composition ” is important. When people lose weight, some of this can be muscle, and this is not generally a good thing. Higher protein diets can reduce the loss of lean mass (including muscle) during weight loss [5].

Overall, there is good evidence, I think, that higher protein diets help weight loss maintenance and lead to improvements in body composition.


1. Delbridge EA, et al One-year weight maintenance after significant weight loss in healthy overweight and obese subjects: does diet composition matter? Am J Clin Nutr 30 September 2009 [epub ahead of print]

2. McAuley KA, et al. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women. Diabetologia 2005;48(1):8-16

3. Claessens M, et al. The effect of a low-fat, high-protein or high-carbohydrate ad libitum diet on weight loss maintenance and metabolic risk factors. Int J Obes (Lond). 2009;33(3):296-304

4. Layman DK, et al. A Moderate-Protein Diet Produces Sustained Weight Loss and Long-Term Changes in Body Composition and Blood Lipids in Obese Adults. Journal of Nutrition. 2009;139: 514-521

5. Krieger JW, et al. Effects of variation in protein and carbohydrate intake on body mass and composition during energy restriction: a meta-regression 1. Am J Clin Nutr. 2006;83(2):260-274

8 Responses to Can higher-protein diets help weight loss maintenance?

  1. jean 2 October 2009 at 5:44 pm #

    It would be helpful if you would also write about how best to keep weight ON. Lots of people have conditions which involve weight loss from poor nutrient absorption, muscle wastage etc and desperately want to GAIN some weight!

  2. Anne 2 October 2009 at 5:58 pm #

    Dear Dr Briffa,

    You wrote:

    “Protein intakes were calculated using food diaries and urine analysis (urea)”

    Can you indicate what the levels of urea where in the higher protein group please ?

    I am a slim diabetic, don’t need to lose weight, I eat a very low carb diet and therefore my diet consists of more fat and protein. Since being on this diet, for 2 1/2 years now, my serum urea levels have always been high – last time they were 11 mnol/L (lab ref range 2.6 – 6.7). My endocrinoligst says I am dehydrated and that is the reason for the high urea but I am not dehydrated ! I always drink plenty and my urine is dilute. I wonder if the high urea is due to protein – I eat roughly 100 -120g per day: 20% calories from protein, 10% from carbs and 70% from fats.

    Does it matter if the urea level is so high when due to protein ? My creatinine levels are normal.


  3. Anne 5 October 2009 at 9:12 am #

    Hi Jean,

    On the low carb diabetes forum I’m on there are several diabetics who are underweight and need to gain weight or have difficulty keeping their weight at normal levels. We are always advised to eat lots of protein as well as fats. Just increasing fats won’t help for some reason to do with the mode of energy burning the body does. So it’s increase the amount of protein a great deal – lots of oily fish such as salmon I have found is good for stabilizing my weight which has a tendency to fall very easily despite eating well over 2,000 calories per day – I eat meat or fish three times a day and have large snacks of nuts such as almonds and walnuts or tahini in between meals. I believe muscle wastage is a sign of protein loss. I don’t eat any grain foods as I’m both intolerant to them and also they raise blood sugars badly. For veggies I leafy green veggies which I stir fry in coconut oil and then liquidize to a purée to help increase absorption of vitamins and minerals.

    all the best,

  4. jacqueline 5 October 2009 at 12:56 pm #

    Dear Dr. Briffa,

    Thank you for all the work you do to keep us so up-to-date with what’s healthy.

    I also would love to hear your observations on the healthiest way to gain weight. I realized I was orthorexic and have lost too much weight—from 9st.7lb all my adult life, to 7st.2lb for the last two years. I’ve been trying to to regain some weight, but although I eat good-sized meals, I stay at 7st.2lb. I’ve had check-ups about it, am 77, and have been pronounced healthy. I feel fit and energetic and am active, but look rather too thin, to put it mildly.


  5. Dianna 3 July 2010 at 12:52 am #

    I can testify to the fact that I need a higher ratio of protein in my diet not just for weight loss but just for daily living. The amount of sugar recommended by the Pyramid is just too much for me.

  6. Jessie 15 November 2010 at 3:14 pm #

    A high protein diet definitely helps you to lose weight, it keeps you fuller for longer so that you ont find yourself reaching for the biscuit tin. I tried a high protein diet delivery service from and lost 4lbs in a week, I feel great and I didn’t have to cook anything ; )


  1. Weight Lose Tips - 24 January 2010

    Top Tips For Weight Lose Diets Reviews!…

    By. Lou Son Weight lose diets becomes as something that many people looking for the way. Actually, there are many ways as the following tips to diet but it is still difficult to be successfully diet. Here, it is provided to you the following tips that …

  2. What Is A High Protein Diet Foods | Diet Plans That Work - 19 September 2011

    […] just check out the site to understand why this happens! http What Is A High Protein Diet Foods What Is A High Protein Diet Foods It is not a secret at all, all of us kno…55" allowfullscreen="true"> What Is A High Protein Diet Foods It is not a […]

Leave a Reply